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		<title>Il padre contemporaneo</title>
		<link>http://www.hygeiapress.com/individualizedmedicine/il-padre-contemporaneo-un-saggio-sulla-figura-paterna-tra-storia-e-mondo-contemporaneo/</link>
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				<content:encoded><![CDATA[<h4><a href="#acquista">acquista</a> | <a href="#descrizione">descrizione</a> | <a href="#indice">indice</a> | <a href="#sfoglia">sfoglia</a> | <a href="#recensioni">recensioni</a> | <a href="#intervista">intervista</a></h4>
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<h3>Come acquistare questo libro</h3>
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<p><a name="descrizione"></a></p>
<h3>Descrizione</h3>
<p><img alt="Il padre contemporaneo" src="https://farm3.staticflickr.com/2662/4029517632_abe4e58180_o.jpg" width="323" height="481" /></p>
<h2>&#8220;Il padre contemporaneo&#8221;, a cura di Marinella Corridori, Thamianos Fanos e Vassilios Fanos</h2>
<h3>ISBN 9788898636006, collana: Saggi, 208 pagine, € 24,95, <strong>seconda edizione</strong>: marzo 2014</h3>
<p>Autori: Rino Agostiniani, Carlo Aresti, Alessandra Atzei, Emanuele Basile, Silvana Carta, Luigi Cataldi, Giampietro Chiamenti, Chiara Ciampi, Elisabetta Coni, Marinella Corridori, Ernesto d’Aloja, Nicola D’Angelo, Anna de Magistris, Angelica Dessì, Gianpaolo Donzelli, Armando Faa, Eleonora Fanos, Thamianos Fanos, Vassilios Fanos, Francesca Farnetani, Italo Farnetani, Marzia Guarnieri, Luigi Memo, Melania Puddu, Loredana Spaccaterra, Gianfranco Temporin, Francesco Tregnaghi, Marco Zaffanello</p>
<p>Il padre è ancora un eroe per i propri figli? Garantisce una presenza adeguata nella loro vita? Da queste domande è iniziata una ricerca sulla realtà italiana, che ha coinvolto numerosi esperti in medicina, psicologia, diritto e storia. <strong>Il padre contemporaneo</strong>, non più proiettato esclusivamente verso una dimensione pubblica, è alla ricerca di un nuovo spazio privato: partecipa al momento del <strong>parto</strong>, contribuisce a prestare le prime cure al bambino, accetta di farsi coinvolgere nell’<strong>accudimento dei figli</strong> e nei loro giochi.<br />
Tuttavia, proprio nel momento in cui l’esame del DNA consente finalmente la certezza della paternità biologica, la sicurezza nell’affrontare il <strong>ruolo paterno</strong> sembra diminuire: la <strong>depressione post partum maschile</strong> è un fenomeno ormai riconosciuto, l’autorevolezza paterna è minata dal timore del giudizio dei figli, <strong>l’assenza o l’inadeguatezza del padre</strong> può creare nei ragazzi un profondo malessere, esplicitato in disturbi comportamentali o in atti violenti, dal <strong>bullismo</strong> fino al <strong>patricidio</strong>.<br />
In uno scenario incerto e in gran parte ancora da decodificare, questo saggio sottolinea quanto sia importante riconoscere la <strong>peculiarità della figura paterna</strong> nel ruolo di collegamento tra il figlio e il mondo.<br />
L’analisi sviluppata in questo libro si estende sino a comprendere in una visione complessiva le radici storiche, le basi psicologiche, gli aspetti medici, le implicazioni legali e i risvolti culturali odierni della paternità. Ne emerge un ritratto variegato del padre di oggi e accanto a lui di tutta la famiglia, attualmente al centro di un’autentica rivoluzione.</p>
<p><strong>A quattro anni dall&#8217;uscita della prima edizione</strong>, si ripropone questo testo, opportunamente <strong>aggiornato</strong>, in una situazione in cui tutto sembra cambiare velocemente e inesorabilmente.</p>
<hr />
<p><a name="indice"></a></p>
<h3>Indice</h3>
<p><strong>Prefazione</strong> <em>di Hercília Guimarães </em></p>
<p><strong>Prefazione</strong> <em>di Pasquale di Pietro</em></p>
<p><strong>Prefazione</strong> <em>di Paolo Giliberti</em></p>
<p><strong>Introduzione</strong></p>
<p><strong>Introduzione alla seconda edizione</strong></p>
<p><strong>1. Nuovi padri, nuovi genitori</strong><br />
<em>Marinella Corridori, Rino Agostiniani, Luigi Cataldi, Vassilios Fanos</em><br />
Il coparenting • Padri high care e low care • Padri sempre più attempati • Padri con pochi figli • Le nuove famiglie • Da “madre” e “padre” a “progenitore A” e “progenitore B” • Da “padre” a “donatore di sperma” • Conclusioni</p>
<p><strong>2. Miti e archetipi della figura paterna</strong><br />
<em>Thamianos Fanos</em><br />
La presenza maschile nei miti delle origini • I padri eroi • Il padre nelle tragedie greche • L’importanza dell’archetipo paterno nell’inconscio • Dal mito all’attualità</p>
<p><strong>3. Una paternità solitaria: il sogno proibito dell’uomo</strong><br />
<em>Marinella Corridori, Vassilios Fanos</em><br />
Le nascite dal mare, dal suolo e dalla pietra • Le nascite anomale di Atena e Dioniso • L’ostetrico e la levatrice- uomo • L’allattamento maschile • Nei miti la madre non è sufficiente né necessaria</p>
<p><strong>4. Le radici storiche del padre contemporaneo nel mondo romano</strong><br />
<em>Marinella Corridori, Vassilios Fanos</em><br />
Il matrimonio era l’unica via per la paternità • Il ruolo assoluto del padre al momento della nascita • Il padre provava affetto per i figli? • Il padre inflessibile • Tensioni generazionali</p>
<p><strong>5. Il padre in sala parto ieri, oggi e domani</strong><br />
<em>Marinella Corridori, Anna de Magistris, Vassilios Fanos</em><br />
Ieri: la sala parto, una zona off limits per l’uomo • Oggi: il padre deve essere presente • Domani: il parto party</p>
<p><strong>6. Il ruolo del padre di fronte alla nascita patologica</strong><br />
<em>Emanuele Basile, Luigi Memo</em><br />
La nascita patologica • L’esperienza dei genitori durante il ricovero in Terapia Intensiva Neonatale • La figura paterna</p>
<p><strong>7. Padri di nati pretermine</strong><br />
<em>Loredana Spaccaterra, Gianpaolo Donzelli</em><br />
Di fronte a una nascita pretermine • La funzione di contenitore del padre • Quando il padre non riesce a divenire padre • Le capacità di adattamento della coppia</p>
<p><strong>8. La depressione post partum nel partner maschile</strong><br />
<em>Anna de Magistris, Elisabetta Coni, Melania Puddu</em><br />
Una nascita o più nascite? Le basi psicologiche della transizione alla genitorialità • Il vissuto paterno della gravidanza: un’esplosione di emozioni • L’uomo di fronte alla depressione post partum</p>
<p><strong>9. La paternità prima e dopo il DNA: il punto di vista dell’avvocato</strong><br />
<em>Francesco Tregnaghi</em><br />
Lo strumento della presunzione • L’attribuzione della paternità • La verità della paternità • I limiti alla ricerca della verità genetica</p>
<p><strong>10. La paternità prima e dopo il DNA: il punto di vista del medico legale</strong><br />
<em>Ernesto d’Aloja</em><br />
La risoluzione di un quesito ancestrale • La svolta tecnologica decisiva • I vantaggi dell’impiego dei polimorfismi del DNA</p>
<p><strong>11. Il padre incapace</strong><br />
<em>Nicola D’Angelo</em><br />
Il genitore-specchio • La madre inconsapevole • Il padre incapace • Il vincitore prende tutto • Il padre oggi</p>
<p><strong>12. Il padre nel disegno infantile</strong><br />
<em>Chiara Ciampi, Marzia Guarnieri</em><br />
La figura paterna per il bambino • Il test della famiglia • Scuola Primaria, dai 5 ai 12 anni • Scuola Secondaria, dai 12 ai 16 anni</p>
<p><strong>13. Padri in evoluzione visti dal pediatra</strong><br />
<em>Giampietro Chiamenti, Gianfranco Temporin</em><br />
Sentirsi atavicamente padri in un mondo che cambia • I padri nell’ambulatorio del pediatra di famiglia • Una galleria di padri • Il rapporto tra padri e pediatri di famiglia • I padri in ospedale: gli anni ’70 • I padri in ospedale: gli anni ’80 e ’90</p>
<p><strong>14. Padri autorevoli</strong><br />
<em>Italo Farnetani, Francesca Farnetani</em><br />
Mamma, papà, mammo • Padri di pochi o troppi anni • Lo sbaglio di un padre • Classificazione delle tipologie di padri • Padre autorevole • Padre “in difetto” • Padre “cattivo”</p>
<p><strong>15. Figura paterna e bullismo</strong><br />
<em>Alessandra Atzei, Angelica Dessì, Silvana Carta</em><br />
Vecchi e nuovi bullismi • Quanto è grande il problema? • Primo caso: il padre è assente • Secondo caso: il padre è un bullo a sua volta</p>
<p><strong>16. Perché e come si uccide il padre ovvero gli aspetti medico-legali del patricidio</strong><br />
<em>Carlo Aresti, Ernesto d’Aloja, Armando Faa</em><br />
Aspetti socio-demografici • Rapporto vittima-aggressore: aspetti criminalistici • Mezzi e modus operandi • Aspetti giurisprudenziali • Riflessioni conclusive</p>
<p><strong>17. Padri indimenticabili del cinema</strong><br />
<em>Thamianos Fanos</em><br />
Il padre oscuro • Il padre coraggioso • Il padre perdente • Il padre affettuoso • Altri padri indimenticabili del<br />
cinema</p>
<p><strong>18. Il rapporto tra padre e figlio nella canzone italiana</strong><br />
<em>Eleonora Fanos, Vassilios Fanos</em><br />
Il figlio visto dal padre • Il padre visto dal figlio</p>
<p><strong>19. Padri contemporanei sul web</strong><br />
<em>Marinella Corridori, Marco Zaffanello, Vassilios Fanos</em><br />
I padri dei nostri tempi • L’identikit del padre contempora- neo, come appare sul web</p>
<p><strong>Bibliografia</strong></p>
<p><strong>Indice degli autori </strong></p>
<hr />
<p><a name="sfoglia"></a></p>
<h3>Sfoglia</h3>
<div class="issuuembed" style="width: 100%; height: 700px;" data-configid="3108958/47320231"></div>
<p>&nbsp;</p>
<p>L&#8217;indice del libro si può anche sfogliare a questo <a title="Il padre contemporaneo - Indice" href="http://issuu.com/hygeiapress/docs/il_padre_contemporaneo-hygeia_press" target="_blank">link</a>.</p>
<hr />
<p><a name="recensioni"></a></p>
<h3>Recensioni</h3>
<p>&#8220;<strong>Il padre contemporaneo</strong>&#8221; è un eccellente libro scritto da specialisti nella cura dei bambini, in psichiatria e nell’educazione. Sono sicura che in questo libro troverete le risposte alle vostre domande e molti dubbi verranno risolti. Gli autori, in modo scientifico ma con linguaggio accessibile, sviluppano idee molto interessanti e contribuiscono a migliorare la formazione del padre nelle <strong>famiglie odierne</strong>, permettendo al padre contemporaneo di continuare a essere l’eroe nel cuore dei propri bambini. &#8211; Hercília Guimarães (Presidente UENPS 2008-2010, Unione delle Società Europee di Neonatologia e Perinatologia), ottobre 2009</p>
<p>Finalmente un libro attuale, unico e completo sul ruolo del padre nella <strong>società odierna</strong>.<br />
Il libro evidenzia come nessuno diventi padre spontaneamente, ma solo se lo desidera e lo ricerca. Nel libro vengono trattati temi molto delicati, che aprono al lettore un nuovo universo inesplorato; da come verranno risolti questi problemi dipenderà la <strong>famiglia</strong> e quindi la <strong>società</strong> <strong>del futuro</strong>. Un libro che tutti dovrebbero leggere, favorendo una discussione atta a proporre soluzioni nuove. &#8211; Pasquale Di Pietro (Presidente SIP 2006-2009, Società Italiana di Pediatria), ottobre 2009</p>
<p>In una società alla ricerca, continua e spesso esasperata, di <strong>modelli</strong> più conformi alle attuali realtà, la <strong>paternità</strong> cerca nuovi equilibri senza potersi liberare del fardello della <strong>tradizione</strong>.<br />
Un contrasto tra vecchio e nuovo, che implica concreti rischi di deviazioni con <strong>espressioni patologiche</strong>, destinate ad influenzare, anche pesantemente, il vivere comune.<br />
Agli Autori i nostri complimenti per aver affrontato la problematica nella sua interezza, con il risultato di un’opera di grande interesse non solo per gli addetti ai lavori. &#8211; Paolo Giliberti (Presidente SIN 2009-2012, Società Italiana di Neonatologia), ottobre 2009</p>
<hr />
<p><a name="intervista"></a></p>
<h3>Intervista</h3>
<h3>&#8220;Il padre contemporaneo. Intervista a Marinella Corridori&#8221; sulla rivista Valore Mamma</h3>
<p>L&#8217;intervista è stata pubblicata sulla rivista Valore Mamma (anno II, numero 6, settembre-dicembre 2014). Si può leggere l&#8217;intervista a questo <a href="http://issuu.com/romawebdesign.it/docs/rivista_valore_mamma_settembre-dice/c/slybwcl" target="_blank">link.</a></p>
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		<title>Developmental Nephrology: From Embryology to Metabolomics (EBOOK)</title>
		<link>http://www.hygeiapress.com/individualizedmedicine/developmental-nephrology-from-embryology-to-metabolomics-ebook-an-essay-ebook-about-kidney-disorders/</link>
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		<pubDate>Fri, 13 Sep 2013 08:10:16 +0000</pubDate>
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		<category><![CDATA[Maria Antonietta Marcialis]]></category>
		<category><![CDATA[Maria Cristina Pintus]]></category>
		<category><![CDATA[Maria Dolores Pilloni]]></category>
		<category><![CDATA[Maria Elisabetta Trudu]]></category>
		<category><![CDATA[Mario De Curtis]]></category>
		<category><![CDATA[Martina Bertin]]></category>
		<category><![CDATA[Melania Puddu]]></category>
		<category><![CDATA[Michele Mussap]]></category>
		<category><![CDATA[Morris Shoeneman]]></category>
		<category><![CDATA[Murat Yurdakök]]></category>
		<category><![CDATA[Nataliya Chorny]]></category>
		<category><![CDATA[Nicoletta Iacovidou]]></category>
		<category><![CDATA[Rino Agostiniani]]></category>
		<category><![CDATA[Robert L. Chevalier]]></category>
		<category><![CDATA[Roberto Antonucci]]></category>
		<category><![CDATA[Silvia Visentin]]></category>
		<category><![CDATA[Silvio Maringhini]]></category>
		<category><![CDATA[Sonia Nemolato]]></category>
		<category><![CDATA[Teresa Tomé]]></category>
		<category><![CDATA[Vassilios Fanos]]></category>
		<category><![CDATA[Vincenzo Zanardo]]></category>
		<category><![CDATA[Viviana Marinelli]]></category>

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<p><img alt="DEVELOPMENTAL NEPHROLOGY: FROM EMBRYOLOGY TO METABOLOMICS" src="http://farm6.staticflickr.com/5200/6898932238_8c7117b8cd.jpg" width="358" height="500" /></p>
<h2>&#8220;Developmental Nephrology: From Embryology to Metabolomics&#8221; edited by Vassilios Fanos, Robert L. Chevalier, Gavino Faa, Luigi Cataldi</h2>
<h3>ISBN 9788890651403, 246 pages, PDF, € 59,99, 1st ebook edition: May 2012</h3>
<p>Authors: Rino Agostiniani, Karel Allegaert, Fani Anatolitou, Roberto Antonucci, Jacob V. Aranda, Alessandra Atzei, Luigi Atzori, Luigi Barberini, Kay D. Beharry, Martina Bertin, Luigi Cataldi, Robert L. Chevalier, Nataliya Chorny, Erich Cosmi, Laura Cuzzolin, Ernesto D’Aloja, Mario De Curtis, Angelica Dessì, Gavino Faa, Daniela Fanni, Vassilios Fanos, Gabriele Finco, Helen Georgaki-Angelaki, Clara Gerosa, Hercília Guimarães, Nicoletta Iacovidou, Maria Antonietta Marcialis, Viviana Marinelli, Silvio Maringhini, Alice Melis, Guido Monga, Michele Mussap, Sonia Nemolato, Antonio Noto, Giovanni Ottonello, Maria Dolores Pilloni, Bernadette Pinna, Maria Cristina Pintus, Melania Puddu, Elisabetta Puxeddu, Jacques Rigo, Luigi Ruggeri, Kosmas Sarafidis, Morris Shoeneman, Teresa Tomé, Daniele Trevisanuto, Maria Elisabetta Trudu, Gloria B. Valencia, John N. van den Anker, Silvia Visentin, Murat Yurdakök, Marco Zaffanello, Vincenzo Zanardo</p>
<p>The traditional approach to <strong>kidney disorders</strong> is changing. In the field of diagnostics much innovative research is ongoing: from the “old” <strong>embryology</strong>, revisited and re-interpreted with new eyes in the light of <strong>immunohistochemistry</strong>, up to <strong>metabolomics</strong> the latest “daughter” of <strong>genomics</strong>, the most promising and remarkable of the <strong>&#8220;omics&#8221; disciplines</strong>.</p>
<p>Between these two extremes we find a universe of novelties, ranging from the most recent <strong>urinary biomarkers</strong> to the questions of <strong>nutrition</strong> and <strong>growth</strong>, as well as those of <strong>ethics</strong>, which the new populations of <strong>extremely low birth weight (ELBW) neonates</strong> present to <strong>neonatologists</strong> and <strong>nephrologists</strong>.</p>
<p>The studies on <strong>perinatal programming</strong> expand the temporal horizon of <strong>precocious reduction in the number of nephrons</strong>, both congenital and/or acquired, thus dilating and multiplying the immediate and long-term negative effects. <strong>Neonatal asphyxia</strong>, <strong>obstructive uropathies</strong>, <strong>nephrotoxic drugs</strong> administered to the mother and/or to the neonate, <strong>malnutrition</strong>, <strong>underfeeding</strong>, or <strong>overfeeding</strong> make it necessary to apply all possible preventive measures to ensure the well-being of the kidney. Because of the kidney’s <strong>holistic dimension</strong>, the methodical and rigorous study of <strong>neonatal nephrology</strong> has advanced all aspects of health through the life cycle.</p>
<p>This volume is an update state of the art of the latest discoveries in <strong>neonatal and pediatric nephrology</strong>. These advances will have an even greater impact when the same children reach <strong>adulthood</strong>, and the ultimate consequences of <strong>perinatal care</strong> are unmasked.</p>
<hr />
<p><a name="maintopics"></a></p>
<h3>Main topics</h3>
<p><strong>Aminoglycosides</strong> - <strong>Antifungals</strong> - <strong>Aquaporins</strong> - <strong>Asphyxia</strong> - <strong>Ethical issues</strong> - <strong>Intrauterine growth restriction</strong> - <strong>Italian Neonatal Nephrology Study Group</strong> - <strong>Kidney embryogenesis</strong> - <strong>Metabolomics</strong> - <strong>Nephrotoxicity</strong> - <strong>Non-steroidal anti-inflammatory drugs</strong> - <strong>Nutrition</strong> - <strong>Obstructive uropathy</strong> - <strong>Pediatric nephrogenic syndrome of inappropriate antidiuresis</strong> - <strong>Perinatal programming</strong> - <strong>Pyelonephritis</strong> - <strong>Sepsis</strong> - <strong>Ultrasounds</strong> - <strong>Urinary biomarkers</strong></p>
<hr />
<p><a name="contents"></a></p>
<h3>Contents</h3>
<p><strong>1. Kidney embryogenesis: how to look at old things with new eyes</strong><br />
<em>Gavino Faa, Clara Gerosa, Daniela Fanni, Sonia Nemolato, Guido Monga, Vassilios Fanos</em><br />
A fascinating traffic of cells and tissues • Morphological sequence of events in human kidney development • Molecular regulation of nephrogenesis • Embryology and carcinogenesis: how to better understand kidney tumors by studying tissue expression of transcription factors • Kidney development: can we trace adult kidney behavior to the nine months before birth? • Conclusions and future challenges • References</p>
<p><strong>2. Obstructive uropathy: the state of the art</strong><br />
<em>Robert L. Chevalier</em><br />
Pathogenesis of obstructive uropathy: animal models • Cellular and molecular mechanisms of obstructive renal injury • Renal growth and glomerular injury • Renal tubular injury • Renal interstitial injury • The role of angiotensin • Evaluation and management of upper tract obstruction • Evaluation and management of lower tract obstruction • Long-term follow-up and the future • References</p>
<p><strong>3. Perinatal programming: long-term consequences for the kidney</strong><br />
<em>Melania Puddu, Luigi Cataldi, Gavino Faa, Murat Yurdakök, Silvio Maringhini, Vassilios Fanos</em><br />
Is the neonate the father of the adult? • Developmental programming of the kidney and epigenetics • Low neonatal weight and kidney diseases: a dangerous couple • From epidemiology to the clinic and experimentation&#8230; • …to pathological anatomy • Renal programming in the VLBW and ELBW: old and new • The influence of pre- and postnatal nutrition • The final number of nephrons as the key factor in the health of the kidney and the organism • Drugs and modulation of nephrogenesis • Future directions • References</p>
<p><strong>4. Aquaporins: implications for the newborn infants</strong><br />
<em>Jacob V. Aranda, Elisabetta Puxeddu, Nataliya Chorny, Morris Shoeneman, Gloria B. Valencia, Kay D. Beharry</em><br />
Aquaporins • Clinical relevance for the newborn infant •Aquaporins in the eyes • Renal ontogeny of aquaporins • References</p>
<p><strong>5. Pediatric nephrogenic syndrome of inappropriate antidiuresis</strong><br />
<em>Maria Antonietta Marcialis, Angelica Dessì, Maria Cristina Pintus, Bernadette Pinna, Luigi Ruggeri, Vassilios Fanos</em><br />
Mechanism of action of AVP • Frequency of NSIAD • Symptomatology • Therapy • Future directions • Take-home messages • References</p>
<p><strong>6. Nutrition and kidney in preterm infant</strong><br />
<em>Mario De Curtis, Jacques Rigo</em><br />
Intrauterine growth and kidney development • Effect of nutrition and growth on the kidney in the postnatal period • Hypercalciuria in preterm infants fed human milk • Maturation of renal function • Renal solute load in preterm infants • Metabolic acidosis and feeding of preterm infants • References</p>
<p><strong>7. Vascular and renal problems among infants with intrauterine growth restriction</strong><br />
<em>Vincenzo Zanardo, Martina Bertin, Vassilios Fanos, Silvia Visentin, Daniele Trevisanuto, Erich Cosmi</em><br />
The Barker hypothesis and fetal programming of adult disease • Endothelial dysfunction • Fetal programming and renal consequences • Conclusion • References</p>
<p><strong>8. Antenatal non-steroidal anti-inflammatory drugs and the neonatal kidney</strong><br />
<em>Roberto Antonucci, Marco Zaffanello, Maria Dolores Pilloni, Vassilios Fanos</em><br />
NSAIDs use in pregnancy and the neonatal kidney: general remarks • Placental transfer of NSAIDs • Pathophysiology of COX inhibition • Metabolism and excretion of NSAIDs • Experimental studies in animals • Observational studies in humans • Histopathological findings • Laboratory assessment • Take-home messages • References</p>
<p><strong>9. Renal safety of antifungals and non-steroidal anti-inflammatory drugs in the newborn</strong><br />
<em>Vassilios Fanos, Michele Mussap, Roberto Antonucci, Laura Cuzzolin, Teresa Tomé, Hercília Guimarães</em><br />
Drug-induced renal damage in the newborn • Physiopathology • Renal safety of antifungals • Renal safety of NSAIDs • References</p>
<p><strong>10. Clinical pharmacology of aminoglycosides and the developing kidney</strong><br />
<em>Karel Allegaert, John N. van den Anker</em><br />
Aminoglycoside pharmacokinetics: how does the developing kidney handle aminoglycosides? • Aminoglycoside pharmacodynamics: how do aminoglycosides affect the developing kidney? • Clinical relevance • References</p>
<p><strong>11. The kidney in post-asphyctic syndrome: state of the art</strong><br />
<em>Vassilios Fanos, Luigi Atzori, Angelica Dessì, Ernesto D’Aloja, Gabriele Finco, Gavino Faa</em><br />
How big is the problem? • Physiopathology of postasphyctic kidney damage • Early diagnosis of hypoxic-ischemic kidney damage • Metabolomics in asphyxia • Prediction of acute postasphyctic renal insufficiency • Therapy and prevention • Prognosis • References</p>
<p><strong>12. Renal consequences of perinatal asphyxia: the role of urinary biomarkers</strong><br />
<em>Kosmas Sarafidis</em><br />
AKI in perinatal asphyxia • Diagnosis of AKI in perinatal asphyxia • Biomarkers of AKI • AKI biomarkers and their potential use in perinatal asphyxia • Conclusions • References</p>
<p><strong>13. Metabolomics in perinatal renal asphyxia</strong><br />
<em>Luigi Atzori, Antonio Noto, Luigi Barberini, Nicoletta Iacovidou, Viviana Marinelli, Vassilios Fanos</em><br />
The kidneys: the second highest consumers of oxygen after the brain • Perinatal programming theory • Intrauterine growth restriction • Metabolomics • Biological samples in metabolomics • Metabolomics and renal asphyxia • Conclusions • References</p>
<p><strong>14. Biochemical markers in neonatal sepsis-induced acute kidney injury</strong><br />
<em>Michele Mussap, Vassilios Fanos</em><br />
Neonatal sepsis-induced AKI • Biomarkers for assessing AKI • Biomarkers for assessing systemic inflammation, sepsis, and septic shock • Sepsis-induced AKI biochemical markers • Future prospects • References</p>
<p><strong>15. Ultrasounds and the kidney</strong><br />
<em>Rino Agostiniani</em><br />
The approach to newborns with suspected urinary tract malformations • Ultrasonography examination of the neonatal urinary tract • The Doppler techniques and the new tools • References</p>
<p><strong>16. Pyelonephritis in the newborn</strong><br />
<em>Giovanni Ottonello, Alessandra Atzei, Angelica Dessì, Maria Elisabetta Trudu, Alice Melis, Vassilios Fanos</em><br />
Epidemiology/risk factors • Etiology • Clinical medicine • Diagnosis • Therapy • Conclusions • References</p>
<p><strong>17. Ethical issues in the management of neonates with severe renal failure</strong><br />
<em>Fani Anatolitou, Helen Georgaki-Angelaki</em><br />
Ethical dilemmas • General theoretical basis • Clinical solutions • Quality of life or sanctity of life? • Withholding or withdrawing treatment • Legal aspects • Resource allocation – Socioeconomic factors • Decision-making process • Conclusions • References</p>
<p><strong>18. The Neonatal Nephrology Study Group: 25 years of work</strong><br />
<em>Luigi Cataldi, Gavino Faa, Robert L. Chevalier, Vassilios Fanos; The Italian Society of Neonatology, The Neonatal Nephrology Study Group </em><br />
Investigations • Teaching Program • Future directions • References</p>
<p><strong>Index</strong></p>
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<h3>Description</h3>
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<p><img alt="DEVELOPMENTAL NEPHROLOGY: FROM EMBRYOLOGY TO METABOLOMICS" src="http://farm6.staticflickr.com/5200/6898932238_8c7117b8cd.jpg" width="358" height="500" /></p>
<h2>&#8220;Developmental Nephrology: From Embryology to Metabolomics&#8221; edited by Vassilios Fanos, Robert L. Chevalier, Gavino Faa, Luigi Cataldi</h2>
<h3>ISBN 9788890438929, book series: Systems Medicine, 272 pages, Hardcover, € 80, 1st edition: October 2011</h3>
<p>Authors: Rino Agostiniani, Karel Allegaert, Fani Anatolitou, Roberto Antonucci, Jacob V. Aranda, Alessandra Atzei, Luigi Atzori, Luigi Barberini, Kay D. Beharry, Martina Bertin, Luigi Cataldi, Robert L. Chevalier, Nataliya Chorny, Erich Cosmi, Laura Cuzzolin, Ernesto D’Aloja, Mario De Curtis, Angelica Dessì, Gavino Faa, Daniela Fanni, Vassilios Fanos, Gabriele Finco, Helen Georgaki-Angelaki, Clara Gerosa, Hercília Guimarães, Nicoletta Iacovidou, Maria Antonietta Marcialis, Viviana Marinelli, Silvio Maringhini, Alice Melis, Guido Monga, Michele Mussap, Sonia Nemolato, Antonio Noto, Giovanni Ottonello, Maria Dolores Pilloni, Bernadette Pinna, Maria Cristina Pintus, Melania Puddu, Elisabetta Puxeddu, Jacques Rigo, Luigi Ruggeri, Kosmas Sarafidis, Morris Shoeneman, Teresa Tomé, Daniele Trevisanuto, Maria Elisabetta Trudu, Gloria B. Valencia, John N. van den Anker, Silvia Visentin, Murat Yurdakök, Marco Zaffanello, Vincenzo Zanardo</p>
<p>The traditional approach to <strong>kidney disorders</strong> is changing. In the field of diagnostics much innovative research is ongoing: from the “old” <strong>embryology</strong>, revisited and re-interpreted with new eyes in the light of <strong>immunohistochemistry</strong>, up to <strong>metabolomics</strong> the latest “daughter” of <strong>genomics</strong>, the most promising and remarkable of the <strong>&#8220;omics&#8221; disciplines</strong>.</p>
<p>Between these two extremes we find a universe of novelties, ranging from the most recent <strong>urinary biomarkers</strong> to the questions of <strong>nutrition</strong> and <strong>growth</strong>, as well as those of <strong>ethics</strong>, which the new populations of <strong>extremely low birth weight (ELBW) neonates</strong> present to <strong>neonatologists</strong> and <strong>nephrologists</strong>.</p>
<p>The studies on <strong>perinatal programming</strong> expand the temporal horizon of <strong>precocious reduction in the number of nephrons</strong>, both congenital and/or acquired, thus dilating and multiplying the immediate and long-term negative effects. <strong>Neonatal asphyxia</strong>, <strong>obstructive uropathies</strong>, <strong>nephrotoxic drugs</strong> administered to the mother and/or to the neonate, <strong>malnutrition</strong>, <strong>underfeeding</strong>, or <strong>overfeeding</strong> make it necessary to apply all possible preventive measures to ensure the well-being of the kidney. Because of the kidney’s <strong>holistic dimension</strong>, the methodical and rigorous study of <strong>neonatal nephrology</strong> has advanced all aspects of health through the life cycle.</p>
<p>This volume is an update state of the art of the latest discoveries in <strong>neonatal and pediatric nephrology</strong>. These advances will have an even greater impact when the same children reach <strong>adulthood</strong>, and the ultimate consequences of <strong>perinatal care</strong> are unmasked.</p>
<hr />
<a name="maintopics"><br />
<h3>Main topics</h3>
<p></a><br />
<strong>Aminoglycosides</strong> &#8211; <strong>Antifungals</strong> &#8211; <strong>Aquaporins</strong> &#8211; <strong>Asphyxia</strong> &#8211; <strong>Ethical issues</strong> &#8211; <strong>Intrauterine growth restriction</strong> &#8211; <strong>Italian Neonatal Nephrology Study Group</strong> &#8211; <strong>Kidney embryogenesis</strong> &#8211; <strong>Metabolomics</strong> &#8211; <strong>Nephrotoxicity</strong> &#8211; <strong>Non-steroidal anti-inflammatory drugs</strong> &#8211; <strong>Nutrition</strong> &#8211; <strong>Obstructive uropathy</strong> &#8211; <strong>Pediatric nephrogenic syndrome of inappropriate antidiuresis</strong> &#8211; <strong>Perinatal programming</strong> &#8211; <strong>Pyelonephritis</strong> &#8211; <strong>Sepsis</strong> &#8211; <strong>Ultrasounds</strong> &#8211; <strong>Urinary biomarkers</strong></p>
<hr />
<a name="contents"><br />
<h3>Contents</h3>
<p></a><br />
<strong>1. Kidney embryogenesis: how to look at old things with new eyes</strong><br />
<em>Gavino Faa, Clara Gerosa, Daniela Fanni, Sonia Nemolato, Guido Monga, Vassilios Fanos</em><br />
A fascinating traffic of cells and tissues • Morphological sequence of events in human kidney development • Molecular regulation of nephrogenesis • Embryology and carcinogenesis: how to better understand kidney tumors by studying tissue expression of transcription factors • Kidney development: can we trace adult kidney behavior to the nine months before birth? • Conclusions and future challenges • References</p>
<p><strong>2. Obstructive uropathy: the state of the art</strong><br />
<em>Robert L. Chevalier</em><br />
Pathogenesis of obstructive uropathy: animal models • Cellular and molecular mechanisms of obstructive renal injury • Renal growth and glomerular injury • Renal tubular injury • Renal interstitial injury • The role of angiotensin • Evaluation and management of upper tract obstruction • Evaluation and management of lower tract obstruction • Long-term follow-up and the future • References</p>
<p><strong>3. Perinatal programming: long-term consequences for the kidney</strong><br />
<em>Melania Puddu, Luigi Cataldi, Gavino Faa, Murat Yurdakök, Silvio Maringhini, Vassilios Fanos</em><br />
Is the neonate the father of the adult? • Developmental programming of the kidney and epigenetics • Low neonatal weight and kidney diseases: a dangerous couple • From epidemiology to the clinic and experimentation&#8230; • …to pathological anatomy • Renal programming in the VLBW and ELBW: old and new • The influence of pre- and postnatal nutrition • The final number of nephrons as the key factor in the health of the kidney and the organism • Drugs and modulation of nephrogenesis • Future directions • References</p>
<p><strong>4. Aquaporins: implications for the newborn infants</strong><br />
<em>Jacob V. Aranda, Elisabetta Puxeddu, Nataliya Chorny, Morris Shoeneman, Gloria B. Valencia, Kay D. Beharry</em><br />
Aquaporins • Clinical relevance for the newborn infant •Aquaporins in the eyes • Renal ontogeny of aquaporins • References</p>
<p><strong>5. Pediatric nephrogenic syndrome of inappropriate antidiuresis</strong><br />
<em>Maria Antonietta Marcialis, Angelica Dessì, Maria Cristina Pintus, Bernadette Pinna, Luigi Ruggeri, Vassilios Fanos</em><br />
Mechanism of action of AVP • Frequency of NSIAD • Symptomatology • Therapy • Future directions • Take-home messages • References</p>
<p><strong>6. Nutrition and kidney in preterm infant</strong><br />
<em>Mario De Curtis, Jacques Rigo</em><br />
Intrauterine growth and kidney development • Effect of nutrition and growth on the kidney in the postnatal period • Hypercalciuria in preterm infants fed human milk • Maturation of renal function • Renal solute load in preterm infants • Metabolic acidosis and feeding of preterm infants • References</p>
<p><strong>7. Vascular and renal problems among infants with intrauterine growth restriction</strong><br />
<em>Vincenzo Zanardo, Martina Bertin, Vassilios Fanos, Silvia Visentin, Daniele Trevisanuto, Erich Cosmi</em><br />
The Barker hypothesis and fetal programming of adult disease • Endothelial dysfunction • Fetal programming and renal consequences • Conclusion • References</p>
<p><strong>8. Antenatal non-steroidal anti-inflammatory drugs and the neonatal kidney</strong><br />
<em>Roberto Antonucci, Marco Zaffanello, Maria Dolores Pilloni, Vassilios Fanos</em><br />
NSAIDs use in pregnancy and the neonatal kidney: general remarks • Placental transfer of NSAIDs • Pathophysiology of COX inhibition • Metabolism and excretion of NSAIDs • Experimental studies in animals • Observational studies in humans • Histopathological findings • Laboratory assessment • Take-home messages • References</p>
<p><strong>9. Renal safety of antifungals and non-steroidal anti-inflammatory drugs in the newborn</strong><br />
<em>Vassilios Fanos, Michele Mussap, Roberto Antonucci, Laura Cuzzolin, Teresa Tomé, Hercília Guimarães</em><br />
Drug-induced renal damage in the newborn • Physiopathology • Renal safety of antifungals • Renal safety of NSAIDs • References</p>
<p><strong>10. Clinical pharmacology of aminoglycosides and the developing kidney</strong><br />
<em>Karel Allegaert, John N. van den Anker</em><br />
Aminoglycoside pharmacokinetics: how does the developing kidney handle aminoglycosides? • Aminoglycoside pharmacodynamics: how do aminoglycosides affect the developing kidney? • Clinical relevance • References</p>
<p><strong>11. The kidney in post-asphyctic syndrome: state of the art</strong><br />
<em>Vassilios Fanos, Luigi Atzori, Angelica Dessì, Ernesto D’Aloja, Gabriele Finco, Gavino Faa</em><br />
How big is the problem? • Physiopathology of postasphyctic kidney damage • Early diagnosis of hypoxic-ischemic kidney damage • Metabolomics in asphyxia • Prediction of acute postasphyctic renal insufficiency • Therapy and prevention • Prognosis • References</p>
<p><strong>12. Renal consequences of perinatal asphyxia: the role of urinary biomarkers</strong><br />
<em>Kosmas Sarafidis</em><br />
AKI in perinatal asphyxia • Diagnosis of AKI in perinatal asphyxia • Biomarkers of AKI • AKI biomarkers and their potential use in perinatal asphyxia • Conclusions • References</p>
<p><strong>13. Metabolomics in perinatal renal asphyxia</strong><br />
<em>Luigi Atzori, Antonio Noto, Luigi Barberini, Nicoletta Iacovidou, Viviana Marinelli, Vassilios Fanos</em><br />
The kidneys: the second highest consumers of oxygen after the brain • Perinatal programming theory • Intrauterine growth restriction • Metabolomics • Biological samples in metabolomics • Metabolomics and renal asphyxia • Conclusions • References</p>
<p><strong>14. Biochemical markers in neonatal sepsis-induced acute kidney injury</strong><br />
<em>Michele Mussap, Vassilios Fanos</em><br />
Neonatal sepsis-induced AKI • Biomarkers for assessing AKI • Biomarkers for assessing systemic inflammation, sepsis, and septic shock • Sepsis-induced AKI biochemical markers • Future prospects • References</p>
<p><strong>15. Ultrasounds and the kidney</strong><br />
<em>Rino Agostiniani</em><br />
The approach to newborns with suspected urinary tract malformations • Ultrasonography examination of the neonatal urinary tract • The Doppler techniques and the new tools • References</p>
<p><strong>16. Pyelonephritis in the newborn</strong><br />
<em>Giovanni Ottonello, Alessandra Atzei, Angelica Dessì, Maria Elisabetta Trudu, Alice Melis, Vassilios Fanos</em><br />
Epidemiology/risk factors • Etiology • Clinical medicine • Diagnosis • Therapy • Conclusions • References</p>
<p><strong>17. Ethical issues in the management of neonates with severe renal failure</strong><br />
<em>Fani Anatolitou, Helen Georgaki-Angelaki</em><br />
Ethical dilemmas • General theoretical basis • Clinical solutions • Quality of life or sanctity of life? • Withholding or withdrawing treatment • Legal aspects • Resource allocation – Socioeconomic factors • Decision-making process • Conclusions • References</p>
<p><strong>18. The Neonatal Nephrology Study Group: 25 years of work</strong><br />
<em>Luigi Cataldi, Gavino Faa, Robert L. Chevalier, Vassilios Fanos; The Italian Society of Neonatology, The Neonatal Nephrology Study Group </em><br />
Investigations • Teaching Program • Future directions • References</p>
<p><strong>Index</strong></p>
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