How to buy this book

Order this book on Amazon!

Order this book on IBS!

IBS provides international delivery, you can read the delivery rates here: IBS delivery rates.

This book is also available in the bookshops listed on the page “HOW TO ORDER – COME ORDINARE“.

For more information about this book, please send us an email at: hygeiapress@hygeiapress.com.

Description

“Perinatal Pharmacology: Individualized Neonatal Therapy” edited by Jacob V. Aranda, Vassilios Fanos, John N. van den Anker

ISBN 9788890651434, book series: Systems Medicine, 352 pages, Hardcover, € 90, 1st edition: October 2012

Authors: Massimo Agosti, Karel Allegaert, Jacob V. Aranda, Salvatore Aversa, Caterina Silvia Barbàra, Ignazio Barberi, Pier Paolo Bassareo, Kay Beharry, Paolo Biban, Giuseppe Buonocore, Daniel Canal-Tristancho, Maria Grazia Capretti, Virgilio P. Carnielli, Elio Castagnola, Massimo Castagnola, Carla Cerasaro, Francesca Ciuffini, Paola E. Cogo, Mariarosa Colnaghi, Giovanni Corsello, Laura Cuzzolin, Roosmarijn De Cock, Sahera Dirajlal-Fargo, Gavino Faa, Daniela Fanni, Vassilios Fanos, Daniele Farina, Monica Fumagalli, Bruna Gabriele, Clara Gerosa, Yukio Gibo, Eloisa Gitto, Mario Giuffrè, Maria Beatriz Guedes, Hercília Guimarães, Nicoletta Iacovidou, Eveline Jacqz-Aigrain, Spyros Kloudas, Catherijne Knibbe, Amir Lahav, Marcello Lanari, Douglas R. Lazarro, Tiziana Lazzarotto, Paolo Manzoni, Lucia Marseglia, Giuseppe Mercuro, Fabio Midulla, Corrado Moretti, Fabio Mosca, Sonia Nemolato, Stefano Nobile, Eren Özek, Paola Papoff, Serafina Perrone, Valentina Polimeni, Natella Y. Rakhmanina, Gustavo Rocha, Serena Salvadei, Davide Silvagni, Henrique Soares, Paulo Soares, Paola Sogno Valin, Gemma Stazzoni, Mauro Stronati, Aggeliki Syggelou, Maria Luisa Tataranno, Gloria B. Valencia, John N. van den Anker, Bart Van Overmeire, Theodoros Xanthos, Murat Yurdakök, Emily Zimmerman

The origin of this book lies on the awareness that we have to do more for identifying unmet needs and improving a tailor-made treatment for each newborn.

After a large introduction on developmental pharmacology, this book analyses in detail new advances on antibiotics (aminoglycosides), antifungals, antivirals (CMV, RSV, HIV), analgosedatives, steroids, caffeine, and cardiovascular drugs. An updated pharmacologic treatment of respiratory diseases (respiratory distress syndrome, meconium aspiration syndrome, chronic lung disease, persistent pulmonary hypertension) is presented, as well as for persistent patent ductus arteriosus and retinopathy of prematurity. Finally, neuroprotection is considered, with special emphasis on antioxidants and melatonin.

A special part is devoted to drug-induced renal toxicity and liver toxicity and completes the volume, also quoting the so-called ‘-omics‘ sciences such as genomics and metabolomics.

The topics are covered by international experts in the field and the subtle red line that links all the chapters together is the perspective of individualized treatments to reach our ultimate goal: the right therapy for each newborn without any side effects.

Main topics

Aminoglycosides – Analgosedatives – Antifungals – Antioxidants – Antivirals (CMV, RSV, HIV) – Caffeine – Cardiovascular drugs – Chronic lung disease – Drug-induced liver
toxicity – Drug-induced renal toxicity – Genomics – Meconium aspiration syndrome – Melatonin – Metabolomics – Neuroprotection – Persistent patent ductus arteriosus – Persistent pulmonary hypertension – Respiratory distress syndrome – Retinopathy of prematurity – Steroids

Contents

Contributors

Preface

Abbreviations

1. Developmental pharmacology
John N. van den Anker, Natella Y. Rakhmanina, Karel Allegaert
Drug absorption • Drug distribution • Drug metabolism • Phase I enzymes • Drug excretion • Other factors influencing the absorption, distribution, metabolism and excretion of drugs in neonates and young infants • Pharmacogenomics: impact for pediatric populations • Developmental pharmacodynamics • Conclusions • References

2. Drug-induced liver injury in neonates: a developmental approach
Gavino Faa, Daniela Fanni, Clara Gerosa, Sonia Nemolato, Yukio Gibo, Massimo Castagnola, Vassilios Fanos
Pharmacokinetics in neonates • Drug-induced liver injury in neonates • Liver disease due to widely utilized drugs in newborns • Conclusions and future challenges • References

3. Influence of prenatal drug treatments on kidney function during fetal and neonatal life
Laura Cuzzolin, Vassilios Fanos
Pathophysiological mechanisms and renal syndromes • Prenatal exposure to drugs • Conclusions • References

4. Excipients in neonatal drug formulations: friend and foe?
Roosmarijn De Cock, Catherijne Knibbe, Karel Allegaert
About the compounds we routinely administer, but never prescribe • The STEP database • The ESNEE research initiative • The Leuven propylene glycol research project to illustrate feasibility and limitations • Perspectives • References

5. Pharmacotoxic effects of aminoglycosides and loud environmental noise: an overlooked risk for hearing loss in preterm infants
Amir Lahav, Emily Zimmerman
The prevalence of hearing loss in preterm neonates • From the protected environment of the womb to the ototoxic environment in the neonatal intensive care unit • Aminoglycosides-induced ototoxicity • Synergistic ototoxicity induced by aminoglycoside and noise exposure • Implications for clinical care •
References

6. Clinical pharmacology of analgosedatives in neonates: between the hammer and the anvil?
Karel Allegaert, John N. van den Anker
On the relevance of (in)adequate analgesia in neonates • Clinical pharmacology of analgesics: from pharmacokinetics towards pharmacodynamics • New compounds: new tools or new toys? • Clinical practice: between the hammer and the anvil? • References

7. New treatments of persistent pulmonary hypertension of the newborn
Nicoletta Iacovidou, Aggeliki Syggelou, Spyros Kloudas, Theodoros Xanthos
Definitions • Pulmonary vasculature physiology – Pathophysiology of PPHN • Etiology of PPHN – Classification – Predisposing factors • Diagnosis of PPHN • Management of PPHN • References

8. Inotropic and vasopressor drugs in the newborn
Hercília Guimarães, Gustavo Rocha, Paulo Soares, Henrique Soares, Maria Beatriz Guedes
Inotropic agents • Epinephrine • Norepinephrine • Dopamine • Dobutamine • Isoproterenol • Milrinone • Levosimendan • References

9. Role of vasopressin and terlipressin in newborns and infants with hypotension and shock
Paolo Biban, Davide Silvagni
Biology of endogenous vasopressin • Role of endogenous vasopressin in shock • Pharmacology of vasopressin and terlipressin • Exogenous vasopressin and terlipressin in neonatal and pediatric shock • Safety and adverse effects of vasopressin and terlipressin • Conclusions • References

10. Pharmacological treatment of patent ductus arteriosus: the last days of indomethacin?
Bart Van Overmeire
Indomethacin • Ibuprofen, the preferred drug? • Gastrointestinal effects of NSAIDs • Renal adverse effects of NSAIDs • Pulmonary hypertension • Bilirubin and ibuprofen • Appropriate NSAIDs dosing • Adapted ibuprofen dosing • Oral administration • Paracetamol? • Conclusion • References

11. The role of caffeine in neonatology
Pier Paolo Bassareo, Vassilios Fanos, Giuseppe Mercuro
Caffeine: short-term effects • Caffeine: long-term effects • Conclusions • References

12. Pulmonary surfactant in newborn infants
Virgilio P. Carnielli, Stefano Nobile, Paola E. Cogo
Background and history • Composition and pharmacodynamics • Methods for pharmacokinetic studies • Surfactant therapy • References

13. Meconium aspiration syndrome: do we know the treatment?
Murat Yurdakök
Pathophysiology of meconium aspiration syndrome • Prophylaxis of meconium aspiration • Management of infants with meconium aspiration • Conclusions • References

14. Treatment of chronic lung disease
Fabio Mosca, Valentina Polimeni, Francesca Ciuffini, Massimo Agosti, Monica Fumagalli, Mariarosa Colnaghi
Caffeine • Diuretics • Postnatal corticosteroids • Surfactant • Bronchodilators • Inhaled nitric oxide • Pulmonary vasodilators • Anti-oxidants • Stem cells • Conclusion • References

15. Postnatal steroids for the prevention and treatment of bronchopulmonary dysplasia
Eren Özek
Postnatal corticosteroids for bronchopulmonary dysplasia • Background • Current evidence of postnatal steroid use • Choice of glucocorticoids • Timing, dosage and duration of corticosteroids • Other systemic or inhaled glucocorticoids • Summary of current evidence based recommendations • References

16. Molecular and clinical pharmacology of retinopathy of prematurity
Kay D. Beharry, Jacob V. Aranda, Daniel Canal-Tristancho, Gloria B. Valencia, Douglas R. Lazarro
Epidemiology and clinical considerations • Pharmacologic interventions in ROP • Caffeine • NSAIDs and COX blockade in ROP • Antioxidant use in ROP • Long chain polyunsaturated fatty acids (LCPUFA) • Growth factors, IGF-1, VEGF and VEGF-antibodies • Beta-blockers • Other pharmacologic interventions • Summary • References

17. How to treat hypoxic-ischemic encephalopathy with drugs
Serafina Perrone, Gemma Stazzoni, Maria Luisa Tataranno, Giuseppe Buonocore
Pathophysiology of HIE • Promising pharmacological interventions • Combined therapies • Conclusions • References

18. Does the best antioxidant come from the brain? Melatonin for the newborn: present and future
Ignazio Barberi, Salvatore Aversa, Lucia Marseglia, Eloisa Gitto
Utility of melatonin in newborns • Future prospectives • References

19. Invasive fungal infections in the nursery: the state of the art
Paolo Manzoni, Elio Castagnola, Eveline Jacqz-Aigrain, Mauro Stronati, Daniele Farina
Risk factors • Prevention • Treatment of neonatal invasive fungal disease: antifungal drugs • References

20. News on management of Cytomegalovirus infections
Marcello Lanari, Maria Grazia Capretti, Paola Sogno Valin, Tiziana Lazzarotto
Prenatal strategies to prevent CMV congenital infection • Neonatal diagnosis of CMV congenital infection • Postnatal CMV infection transmitted via mother’s milk • Neuroimaging of CMV congenital infected newborns • CMV and antiviral therapy • Conclusions • References

21. Global (pharmacological and non pharmacological) prevention of RSV infection
Giovanni Corsello, Bruna Gabriele, Mario Giuffrè
Respiratory syncytial virus infections • Non pharmacological prophylaxis • Pharmacological prophylaxis • Conclusions • References

22. Clinical review of pharmacologic agents for infants with severe viral bronchiolitis
Corrado Moretti, Paola Papoff, Carla Cerasaro, Caterina Silvia Barbàra, Serena Salvadei, Fabio Midulla
Antibiotics • Beta agonists, epinephrine and hypertonic saline • Corticosteroids • DNase • Caffeine • Surfactant • Anesthetics • Conclusions • References

23. Perinatal antiretroviral therapy
Natella Y. Rakhmanina, Sahera Dirajlal-Fargo, John N. van den Anker
Antiretroviral therapy during pregnancy and delivery • Neonatal antiretroviral prophylaxis • Safety of perinatal antiretroviral therapy • Conclusions • References

Index

Look inside

You can also view the book’s table of contents at this link.

Flyer

You can download a book flyer here.

The post Perinatal Pharmacology: Individualized Neonatal Therapy appeared first on Hygeia Press.

How to buy this ebook

Order this book on Amazon!

You can find the ebook “Developmental Nephrology: From Embryology to Metabolomics” in many Amazon stores: amazon.com, amazon.co.uk, amazon.it, amazon.es, amazon.de and amazon.fr. Moreover, you can find this ebook in many other ebookstores (with Italian interface): IBS.it, ultimabooks.it, bookrepublic.it, hoepli.it, sanpaolostore.it, etc.

Description

“Developmental Nephrology: From Embryology to Metabolomics” edited by Vassilios Fanos, Robert L. Chevalier, Gavino Faa, Luigi Cataldi

ISBN 9788890651403, 246 pages, PDF, € 59,99, 1st ebook edition: May 2012

Authors: Rino Agostiniani, Karel Allegaert, Fani Anatolitou, Roberto Antonucci, Jacob V. Aranda, Alessandra Atzei, Luigi Atzori, Luigi Barberini, Kay D. Beharry, Martina Bertin, Luigi Cataldi, Robert L. Chevalier, Nataliya Chorny, Erich Cosmi, Laura Cuzzolin, Ernesto D’Aloja, Mario De Curtis, Angelica Dessì, Gavino Faa, Daniela Fanni, Vassilios Fanos, Gabriele Finco, Helen Georgaki-Angelaki, Clara Gerosa, Hercília Guimarães, Nicoletta Iacovidou, Maria Antonietta Marcialis, Viviana Marinelli, Silvio Maringhini, Alice Melis, Guido Monga, Michele Mussap, Sonia Nemolato, Antonio Noto, Giovanni Ottonello, Maria Dolores Pilloni, Bernadette Pinna, Maria Cristina Pintus, Melania Puddu, Elisabetta Puxeddu, Jacques Rigo, Luigi Ruggeri, Kosmas Sarafidis, Morris Shoeneman, Teresa Tomé, Daniele Trevisanuto, Maria Elisabetta Trudu, Gloria B. Valencia, John N. van den Anker, Silvia Visentin, Murat Yurdakök, Marco Zaffanello, Vincenzo Zanardo

The traditional approach to kidney disorders is changing. In the field of diagnostics much innovative research is ongoing: from the “old” embryology, revisited and re-interpreted with new eyes in the light of immunohistochemistry, up to metabolomics the latest “daughter” of genomics, the most promising and remarkable of the “omics” disciplines.

Between these two extremes we find a universe of novelties, ranging from the most recent urinary biomarkers to the questions of nutrition and growth, as well as those of ethics, which the new populations of extremely low birth weight (ELBW) neonates present to neonatologists and nephrologists.

The studies on perinatal programming expand the temporal horizon of precocious reduction in the number of nephrons, both congenital and/or acquired, thus dilating and multiplying the immediate and long-term negative effects. Neonatal asphyxia, obstructive uropathies, nephrotoxic drugs administered to the mother and/or to the neonate, malnutrition, underfeeding, or overfeeding make it necessary to apply all possible preventive measures to ensure the well-being of the kidney. Because of the kidney’s holistic dimension, the methodical and rigorous study of neonatal nephrology has advanced all aspects of health through the life cycle.

This volume is an update state of the art of the latest discoveries in neonatal and pediatric nephrology. These advances will have an even greater impact when the same children reach adulthood, and the ultimate consequences of perinatal care are unmasked.

Main topics

Aminoglycosides - Antifungals - Aquaporins - Asphyxia - Ethical issues - Intrauterine growth restriction - Italian Neonatal Nephrology Study Group - Kidney embryogenesis - Metabolomics - Nephrotoxicity - Non-steroidal anti-inflammatory drugs - Nutrition - Obstructive uropathy - Pediatric nephrogenic syndrome of inappropriate antidiuresis - Perinatal programming - Pyelonephritis - Sepsis - Ultrasounds - Urinary biomarkers

Contents

1. Kidney embryogenesis: how to look at old things with new eyes
Gavino Faa, Clara Gerosa, Daniela Fanni, Sonia Nemolato, Guido Monga, Vassilios Fanos
A fascinating traffic of cells and tissues • Morphological sequence of events in human kidney development • Molecular regulation of nephrogenesis • Embryology and carcinogenesis: how to better understand kidney tumors by studying tissue expression of transcription factors • Kidney development: can we trace adult kidney behavior to the nine months before birth? • Conclusions and future challenges • References

2. Obstructive uropathy: the state of the art
Robert L. Chevalier
Pathogenesis of obstructive uropathy: animal models • Cellular and molecular mechanisms of obstructive renal injury • Renal growth and glomerular injury • Renal tubular injury • Renal interstitial injury • The role of angiotensin • Evaluation and management of upper tract obstruction • Evaluation and management of lower tract obstruction • Long-term follow-up and the future • References

3. Perinatal programming: long-term consequences for the kidney
Melania Puddu, Luigi Cataldi, Gavino Faa, Murat Yurdakök, Silvio Maringhini, Vassilios Fanos
Is the neonate the father of the adult? • Developmental programming of the kidney and epigenetics • Low neonatal weight and kidney diseases: a dangerous couple • From epidemiology to the clinic and experimentation… • …to pathological anatomy • Renal programming in the VLBW and ELBW: old and new • The influence of pre- and postnatal nutrition • The final number of nephrons as the key factor in the health of the kidney and the organism • Drugs and modulation of nephrogenesis • Future directions • References

4. Aquaporins: implications for the newborn infants
Jacob V. Aranda, Elisabetta Puxeddu, Nataliya Chorny, Morris Shoeneman, Gloria B. Valencia, Kay D. Beharry
Aquaporins • Clinical relevance for the newborn infant •Aquaporins in the eyes • Renal ontogeny of aquaporins • References

5. Pediatric nephrogenic syndrome of inappropriate antidiuresis
Maria Antonietta Marcialis, Angelica Dessì, Maria Cristina Pintus, Bernadette Pinna, Luigi Ruggeri, Vassilios Fanos
Mechanism of action of AVP • Frequency of NSIAD • Symptomatology • Therapy • Future directions • Take-home messages • References

6. Nutrition and kidney in preterm infant
Mario De Curtis, Jacques Rigo
Intrauterine growth and kidney development • Effect of nutrition and growth on the kidney in the postnatal period • Hypercalciuria in preterm infants fed human milk • Maturation of renal function • Renal solute load in preterm infants • Metabolic acidosis and feeding of preterm infants • References

7. Vascular and renal problems among infants with intrauterine growth restriction
Vincenzo Zanardo, Martina Bertin, Vassilios Fanos, Silvia Visentin, Daniele Trevisanuto, Erich Cosmi
The Barker hypothesis and fetal programming of adult disease • Endothelial dysfunction • Fetal programming and renal consequences • Conclusion • References

8. Antenatal non-steroidal anti-inflammatory drugs and the neonatal kidney
Roberto Antonucci, Marco Zaffanello, Maria Dolores Pilloni, Vassilios Fanos
NSAIDs use in pregnancy and the neonatal kidney: general remarks • Placental transfer of NSAIDs • Pathophysiology of COX inhibition • Metabolism and excretion of NSAIDs • Experimental studies in animals • Observational studies in humans • Histopathological findings • Laboratory assessment • Take-home messages • References

9. Renal safety of antifungals and non-steroidal anti-inflammatory drugs in the newborn
Vassilios Fanos, Michele Mussap, Roberto Antonucci, Laura Cuzzolin, Teresa Tomé, Hercília Guimarães
Drug-induced renal damage in the newborn • Physiopathology • Renal safety of antifungals • Renal safety of NSAIDs • References

10. Clinical pharmacology of aminoglycosides and the developing kidney
Karel Allegaert, John N. van den Anker
Aminoglycoside pharmacokinetics: how does the developing kidney handle aminoglycosides? • Aminoglycoside pharmacodynamics: how do aminoglycosides affect the developing kidney? • Clinical relevance • References

11. The kidney in post-asphyctic syndrome: state of the art
Vassilios Fanos, Luigi Atzori, Angelica Dessì, Ernesto D’Aloja, Gabriele Finco, Gavino Faa
How big is the problem? • Physiopathology of postasphyctic kidney damage • Early diagnosis of hypoxic-ischemic kidney damage • Metabolomics in asphyxia • Prediction of acute postasphyctic renal insufficiency • Therapy and prevention • Prognosis • References

12. Renal consequences of perinatal asphyxia: the role of urinary biomarkers
Kosmas Sarafidis
AKI in perinatal asphyxia • Diagnosis of AKI in perinatal asphyxia • Biomarkers of AKI • AKI biomarkers and their potential use in perinatal asphyxia • Conclusions • References

13. Metabolomics in perinatal renal asphyxia
Luigi Atzori, Antonio Noto, Luigi Barberini, Nicoletta Iacovidou, Viviana Marinelli, Vassilios Fanos
The kidneys: the second highest consumers of oxygen after the brain • Perinatal programming theory • Intrauterine growth restriction • Metabolomics • Biological samples in metabolomics • Metabolomics and renal asphyxia • Conclusions • References

14. Biochemical markers in neonatal sepsis-induced acute kidney injury
Michele Mussap, Vassilios Fanos
Neonatal sepsis-induced AKI • Biomarkers for assessing AKI • Biomarkers for assessing systemic inflammation, sepsis, and septic shock • Sepsis-induced AKI biochemical markers • Future prospects • References

15. Ultrasounds and the kidney
Rino Agostiniani
The approach to newborns with suspected urinary tract malformations • Ultrasonography examination of the neonatal urinary tract • The Doppler techniques and the new tools • References

16. Pyelonephritis in the newborn
Giovanni Ottonello, Alessandra Atzei, Angelica Dessì, Maria Elisabetta Trudu, Alice Melis, Vassilios Fanos
Epidemiology/risk factors • Etiology • Clinical medicine • Diagnosis • Therapy • Conclusions • References

17. Ethical issues in the management of neonates with severe renal failure
Fani Anatolitou, Helen Georgaki-Angelaki
Ethical dilemmas • General theoretical basis • Clinical solutions • Quality of life or sanctity of life? • Withholding or withdrawing treatment • Legal aspects • Resource allocation – Socioeconomic factors • Decision-making process • Conclusions • References

18. The Neonatal Nephrology Study Group: 25 years of work
Luigi Cataldi, Gavino Faa, Robert L. Chevalier, Vassilios Fanos; The Italian Society of Neonatology, The Neonatal Nephrology Study Group
Investigations • Teaching Program • Future directions • References

Index

Hardcover

If you prefer to read the physical copy of this book, please click here

The post Developmental Nephrology: From Embryology to Metabolomics (EBOOK) appeared first on Hygeia Press.

How to buy this book

Order this book on Amazon!

Order this book on IBS!

IBS provides international delivery, you can read the delivery rates here: IBS delivery rates.

This book is also available in the bookshops listed on the page “HOW TO ORDER – COME ORDINARE“.

For more information about this book, please send us an email at hygeiapress@hygeiapress.com.

“Developmental Nephrology: From Embryology to Metabolomics” edited by Vassilios Fanos, Robert L. Chevalier, Gavino Faa, Luigi Cataldi

ISBN 9788890438929, book series: Systems Medicine, 272 pages, Hardcover, € 80, 1st edition: October 2011

Authors: Rino Agostiniani, Karel Allegaert, Fani Anatolitou, Roberto Antonucci, Jacob V. Aranda, Alessandra Atzei, Luigi Atzori, Luigi Barberini, Kay D. Beharry, Martina Bertin, Luigi Cataldi, Robert L. Chevalier, Nataliya Chorny, Erich Cosmi, Laura Cuzzolin, Ernesto D’Aloja, Mario De Curtis, Angelica Dessì, Gavino Faa, Daniela Fanni, Vassilios Fanos, Gabriele Finco, Helen Georgaki-Angelaki, Clara Gerosa, Hercília Guimarães, Nicoletta Iacovidou, Maria Antonietta Marcialis, Viviana Marinelli, Silvio Maringhini, Alice Melis, Guido Monga, Michele Mussap, Sonia Nemolato, Antonio Noto, Giovanni Ottonello, Maria Dolores Pilloni, Bernadette Pinna, Maria Cristina Pintus, Melania Puddu, Elisabetta Puxeddu, Jacques Rigo, Luigi Ruggeri, Kosmas Sarafidis, Morris Shoeneman, Teresa Tomé, Daniele Trevisanuto, Maria Elisabetta Trudu, Gloria B. Valencia, John N. van den Anker, Silvia Visentin, Murat Yurdakök, Marco Zaffanello, Vincenzo Zanardo

The traditional approach to kidney disorders is changing. In the field of diagnostics much innovative research is ongoing: from the “old” embryology, revisited and re-interpreted with new eyes in the light of immunohistochemistry, up to metabolomics the latest “daughter” of genomics, the most promising and remarkable of the “omics” disciplines.

Between these two extremes we find a universe of novelties, ranging from the most recent urinary biomarkers to the questions of nutrition and growth, as well as those of ethics, which the new populations of extremely low birth weight (ELBW) neonates present to neonatologists and nephrologists.

The studies on perinatal programming expand the temporal horizon of precocious reduction in the number of nephrons, both congenital and/or acquired, thus dilating and multiplying the immediate and long-term negative effects. Neonatal asphyxia, obstructive uropathies, nephrotoxic drugs administered to the mother and/or to the neonate, malnutrition, underfeeding, or overfeeding make it necessary to apply all possible preventive measures to ensure the well-being of the kidney. Because of the kidney’s holistic dimension, the methodical and rigorous study of neonatal nephrology has advanced all aspects of health through the life cycle.

This volume is an update state of the art of the latest discoveries in neonatal and pediatric nephrology. These advances will have an even greater impact when the same children reach adulthood, and the ultimate consequences of perinatal care are unmasked.

Aminoglycosides – Antifungals – Aquaporins – Asphyxia – Ethical issues – Intrauterine growth restriction – Italian Neonatal Nephrology Study Group – Kidney embryogenesis – Metabolomics – Nephrotoxicity – Non-steroidal anti-inflammatory drugs – Nutrition – Obstructive uropathy – Pediatric nephrogenic syndrome of inappropriate antidiuresis – Perinatal programming – Pyelonephritis – Sepsis – Ultrasounds – Urinary biomarkers

1. Kidney embryogenesis: how to look at old things with new eyes
Gavino Faa, Clara Gerosa, Daniela Fanni, Sonia Nemolato, Guido Monga, Vassilios Fanos
A fascinating traffic of cells and tissues • Morphological sequence of events in human kidney development • Molecular regulation of nephrogenesis • Embryology and carcinogenesis: how to better understand kidney tumors by studying tissue expression of transcription factors • Kidney development: can we trace adult kidney behavior to the nine months before birth? • Conclusions and future challenges • References

2. Obstructive uropathy: the state of the art
Robert L. Chevalier
Pathogenesis of obstructive uropathy: animal models • Cellular and molecular mechanisms of obstructive renal injury • Renal growth and glomerular injury • Renal tubular injury • Renal interstitial injury • The role of angiotensin • Evaluation and management of upper tract obstruction • Evaluation and management of lower tract obstruction • Long-term follow-up and the future • References

3. Perinatal programming: long-term consequences for the kidney
Melania Puddu, Luigi Cataldi, Gavino Faa, Murat Yurdakök, Silvio Maringhini, Vassilios Fanos
Is the neonate the father of the adult? • Developmental programming of the kidney and epigenetics • Low neonatal weight and kidney diseases: a dangerous couple • From epidemiology to the clinic and experimentation… • …to pathological anatomy • Renal programming in the VLBW and ELBW: old and new • The influence of pre- and postnatal nutrition • The final number of nephrons as the key factor in the health of the kidney and the organism • Drugs and modulation of nephrogenesis • Future directions • References

4. Aquaporins: implications for the newborn infants
Jacob V. Aranda, Elisabetta Puxeddu, Nataliya Chorny, Morris Shoeneman, Gloria B. Valencia, Kay D. Beharry
Aquaporins • Clinical relevance for the newborn infant •Aquaporins in the eyes • Renal ontogeny of aquaporins • References

5. Pediatric nephrogenic syndrome of inappropriate antidiuresis
Maria Antonietta Marcialis, Angelica Dessì, Maria Cristina Pintus, Bernadette Pinna, Luigi Ruggeri, Vassilios Fanos
Mechanism of action of AVP • Frequency of NSIAD • Symptomatology • Therapy • Future directions • Take-home messages • References

6. Nutrition and kidney in preterm infant
Mario De Curtis, Jacques Rigo
Intrauterine growth and kidney development • Effect of nutrition and growth on the kidney in the postnatal period • Hypercalciuria in preterm infants fed human milk • Maturation of renal function • Renal solute load in preterm infants • Metabolic acidosis and feeding of preterm infants • References

7. Vascular and renal problems among infants with intrauterine growth restriction
Vincenzo Zanardo, Martina Bertin, Vassilios Fanos, Silvia Visentin, Daniele Trevisanuto, Erich Cosmi
The Barker hypothesis and fetal programming of adult disease • Endothelial dysfunction • Fetal programming and renal consequences • Conclusion • References

8. Antenatal non-steroidal anti-inflammatory drugs and the neonatal kidney
Roberto Antonucci, Marco Zaffanello, Maria Dolores Pilloni, Vassilios Fanos
NSAIDs use in pregnancy and the neonatal kidney: general remarks • Placental transfer of NSAIDs • Pathophysiology of COX inhibition • Metabolism and excretion of NSAIDs • Experimental studies in animals • Observational studies in humans • Histopathological findings • Laboratory assessment • Take-home messages • References

9. Renal safety of antifungals and non-steroidal anti-inflammatory drugs in the newborn
Vassilios Fanos, Michele Mussap, Roberto Antonucci, Laura Cuzzolin, Teresa Tomé, Hercília Guimarães
Drug-induced renal damage in the newborn • Physiopathology • Renal safety of antifungals • Renal safety of NSAIDs • References

10. Clinical pharmacology of aminoglycosides and the developing kidney
Karel Allegaert, John N. van den Anker
Aminoglycoside pharmacokinetics: how does the developing kidney handle aminoglycosides? • Aminoglycoside pharmacodynamics: how do aminoglycosides affect the developing kidney? • Clinical relevance • References

11. The kidney in post-asphyctic syndrome: state of the art
Vassilios Fanos, Luigi Atzori, Angelica Dessì, Ernesto D’Aloja, Gabriele Finco, Gavino Faa
How big is the problem? • Physiopathology of postasphyctic kidney damage • Early diagnosis of hypoxic-ischemic kidney damage • Metabolomics in asphyxia • Prediction of acute postasphyctic renal insufficiency • Therapy and prevention • Prognosis • References

12. Renal consequences of perinatal asphyxia: the role of urinary biomarkers
Kosmas Sarafidis
AKI in perinatal asphyxia • Diagnosis of AKI in perinatal asphyxia • Biomarkers of AKI • AKI biomarkers and their potential use in perinatal asphyxia • Conclusions • References

13. Metabolomics in perinatal renal asphyxia
Luigi Atzori, Antonio Noto, Luigi Barberini, Nicoletta Iacovidou, Viviana Marinelli, Vassilios Fanos
The kidneys: the second highest consumers of oxygen after the brain • Perinatal programming theory • Intrauterine growth restriction • Metabolomics • Biological samples in metabolomics • Metabolomics and renal asphyxia • Conclusions • References

14. Biochemical markers in neonatal sepsis-induced acute kidney injury
Michele Mussap, Vassilios Fanos
Neonatal sepsis-induced AKI • Biomarkers for assessing AKI • Biomarkers for assessing systemic inflammation, sepsis, and septic shock • Sepsis-induced AKI biochemical markers • Future prospects • References

15. Ultrasounds and the kidney
Rino Agostiniani
The approach to newborns with suspected urinary tract malformations • Ultrasonography examination of the neonatal urinary tract • The Doppler techniques and the new tools • References

16. Pyelonephritis in the newborn
Giovanni Ottonello, Alessandra Atzei, Angelica Dessì, Maria Elisabetta Trudu, Alice Melis, Vassilios Fanos
Epidemiology/risk factors • Etiology • Clinical medicine • Diagnosis • Therapy • Conclusions • References

17. Ethical issues in the management of neonates with severe renal failure
Fani Anatolitou, Helen Georgaki-Angelaki
Ethical dilemmas • General theoretical basis • Clinical solutions • Quality of life or sanctity of life? • Withholding or withdrawing treatment • Legal aspects • Resource allocation – Socioeconomic factors • Decision-making process • Conclusions • References

18. The Neonatal Nephrology Study Group: 25 years of work
Luigi Cataldi, Gavino Faa, Robert L. Chevalier, Vassilios Fanos; The Italian Society of Neonatology, The Neonatal Nephrology Study Group
Investigations • Teaching Program • Future directions • References

Index

You can also view the book’s table of contents here: link.

You can download a book flyer here.

If you prefer to read the ebook, please click here

The post Developmental Nephrology: From Embryology to Metabolomics appeared first on Hygeia Press.

Ordina questo libro su Amazon!

Ordina questo libro su IBS!

Il libro è inoltre disponibile nelle librerie indicate alla pagina “HOW TO ORDER – COME ORDINARE“.

Per avere ulteriori informazioni puoi scriverci al seguente indirizzo: hygeiapress@hygeiapress.com.

“Figli della Dea Madre. Storia dei neonati nel Mediterraneo” a cura di Vassilios Fanos e Murat Yurdakök

ISBN 9788890438998, 224 pagine, € 24, prima edizione: maggio 2011

Autori: Cristina Areias, Alessandra Atzei, Luigi Cataldi, Marinella Corridori, Giovanni Corsello, Matteo Della Monica, Gian Paolo Donzelli, Thamianos Fanos, Vassilios Fanos, Italo Farnetani, Nadia Maria Filippini, M. Giuseppina Gregorio, Hercília Guimarães, Roberto Mauri, Luigi Memo, Amélia Ricon-Ferraz, Marcella Testa, Teresa Tomé, Francesco Tregnaghi, Kyriakì Tsotra, Alice Vuoso-Mauri, Murat Yurdakök

Questo libro racconta la nascita attraverso la storia, il mito, le arti figurative e i rituali millenari tramandati sullo sfondo del Mediterraneo. Si delineano le radici profonde della nostra civiltà e le trasformazioni intervenute all’interno della famiglia, della società e del sapere medico. L’attenzione si focalizza sul ruolo della donna, sull’accoglienza del neonato, sulla percezione sociale dell’allattamento al seno, e su terreni meno esplorati quali la fertilità e l’adozione. Ne emerge una rappresentazione culturale della nascita divisa tra antiche usanze e una visione sempre più scientifica della gravidanza e del parto.
Questo saggio contribuisce a un approfondimento delle illness narratives, favorendo la ricerca di una convergenza tra il linguaggio medico settoriale e il linguaggio dell’esperienza culturale, perché la evidence based medicine non si contrapponga alla narrative based medicine, ma i due linguaggi convergano verso una complementarità che possa rafforzare l’alleanza tra medico e paziente.

Prefazione di Giuseppe Buonocore

Prefazione di Paolo Giliberti

Prefazione di Gianpaolo Donzelli

Introduzione
Vassilios Fanos, Murat Yurdakök

1. La nascita nella cultura dei popoli mediterranei: una ricerca delle radici
Luigi Cataldi, M. Giuseppina Gregorio
La Dea Madre e l’evoluzione di una cultura • Le sacre nozze della Dea: la cultura mediterranea

2. La nascita nell’antica Anatolia
Murat Yurdakök
12000 anni fa • Il periodo neolitico • Hatti e Ittiti • Il periodo ottomano

3. Nascita e cura del neonato nell’antica Grecia
Vassilios Fanos, Alessandra Atzei, Marinella Corridori
Il parto • I rituali successivi al parto • L’allattamento • Abbandono e infanticidio • L’attaccamento dei genitori ai figli

4. Nascite straordinarie nella sala parto degli dei
Vassilios Fanos, Thamianos Fanos, Marinella Corridori
La nascita di Atena dalla testa di Zeus • La nascita di Dioniso dalla coscia di Zeus • La nascita di Afrodite dal membro di Urano • La nascita di Agdistis e di Erittonio dalla Terra • Quando le madri generano da sole

5. Il neonato e il bambino nella Magna Grecia
Giovanni Corsello
La storia • Tra filosofia, scienza, miti e religione • Il gioco • L’eredità

6. Nascita e cura del neonato nell’antica Roma
Marinella Corridori, Vassilios Fanos
Il ruolo riproduttivo della donna • Le levatrici • La raffigurazione del parto • Fattori ritenuti importanti per il parto: legami e nodi • Divinità e parto • Il parto e le prime cure al neonato • La mortalità neonatale • Il riconoscimento del neonato • L’abbandono (o esposizione) del neonato • Il bagno del neonato, le fasce, la culla • L’allattamento • Il nome

7. Riti di fertilità
Italo Farnetani, Vassilios Fanos, Marinella Corridori
Etnobiologia della riproduzione • I riti di fertilità • Il potere della luce

8. Storia dell’allattamento
Marcella Testa, Kyriakì Tsotra
Gli Egizi • I Greci • Gli Etruschi e i popoli italici • I Romani • Conclusioni

9. Storia dell’adozione
Francesco Tregnaghi
L’adozione in Babilonia • Antico Testamento • Antico Egitto • Antica Grecia • Antica Roma • Il Medio Evo • La Rivoluzione francese • Età moderna: Francia e Italia

10. La medicina neonatale nell’arte antica
Murat Yurdakök
Gli dei egiziani e la nascita • L’allattamento • I primi neonatologi • Il parto cesareo • Il feto • Anomalie congenite • I gemelli • La circoncisione

11. Il neonato malformato nel corso della storia
Luigi Memo, Matteo Della Monica, Roberto Mauri, Alice Vuoso-Mauri
Antico Egitto • Medio Oriente • Mondo classico • Medioevo e Rinascimento • Dal Cinquecento al Settecento • La curiosità vittoriana • L’eugenetica e la follia nazista • Prospettive attuali • Conclusioni

12. “La nascita straordinaria”. Storia del taglio cesareo in Occidente
Nadia Maria Filippini
La nascita degli dei e degli eroi • Il cesareo post mortem • La rivoluzione del Settecento: Gian Battista Bianchi e Francesco Emanuele Cangiamila • Il taglio cesareo sulla donna in vita

13. La nascita nelle tradizioni dei popoli europei
Amélia Ricon-Ferraz, Hercília Guimarães, Cristina Areias, Teresa Tomé
La gravidanza • Il parto • Il puerperio • Il neonato

14. La protezione dell’infanzia: amuleti e talismani
M. Giuseppina Gregorio, Luigi Cataldi
L’amuleto • Il talismano • L’amuleto come gioiello • Oggi • Conclusioni

15. I neonati europei tra passato e futuro
Hercília Guimarães, Amélia Ricon-Ferraz, Cristina Areias, Teresa Tomé
Uno sguardo al passato • Uno sguardo al futuro • NIDCAP (Newborn Individualized Developmental Care and Assessment Program) • Il neonato terminale e le cure palliative • UENPS (Union of European Neonatal and Perinatal Societies) e EFCNI (European Foundation for the Care of Newborn Infants) • La mortalità e la morbidità neonatale • Il prossimo futuro

Appendice. Nascere (Poesie)
Gianpaolo Donzelli
Scelta • Essenza • Presagio • Attesa • Travaglio • Nascita • Vita • Allattamento

Bibliografia

Indice degli autori

L’indice del libro si può anche sfogliare a questo link.

Presentazione durante la Nobel Week Sanremo 2020
La Dott.ssa Marinella Corridori ha presentato il libro “Figli della Dea Madre. Storia dei neonati nel Mediterraneo” durante la Nobel Week Sanremo 2020, evento organizzato da Villa Nobel (Sanremo).

Questo libro tratta di storia e di tradizioni intorno al concepimento, alla nascita e alla cura dei neonati nella cultura europea, in particolare nell’area che gravita verso il Mediterraneo. La storia e le tradizioni fanno parte di un bagaglio culturale che accomuna medici e pazienti e si esplica in un linguaggio condiviso, che rende possibile la comunicazione. – Giuseppe Buonocore (President of the Union of European Neonatal and Perinatal Societies), ottobre 2010

L’evento nascita ha assunto, in tutte le epoche e in tutte le culture, le connotazioni del mito, il tocco del magico, il simbolismo del soprannaturale. Oggi, nel momento in cui affermiamo il diritto del nuovo nato a essere “persona“, ricordare il passato aiuta a trovare le soluzioni giuste alle tante domande, ancora disattese. – Paolo Giliberti (President of the Italian Neonatology Society), ottobre 2010

Nel libro viene con forza ribadito che la nascita è un evento politico e sociale, appartiene alla storia del singolo cittadino-neonato, alla donna e all’uomo da cui nasce, all’intera società. La lettura del libro è indicata per chi opera nelle scienze neonatologiche, pediatriche, perinatologiche, a qualsiasi livello, storico, sanitario, psicologico, sociologico, antropologico, e a tutti gli studenti universitari, nei percorsi di formazione in queste discipline. – Gianpaolo Donzelli (President of the Italian Perinatal Medicine Society), ottobre 2010

This book is also available in English: “Children of the Mother Goddess. History of Mediterranean Neonates”

The post Figli della Dea Madre. Storia dei neonati nel Mediterraneo appeared first on Hygeia Press.

Order this book on Amazon.COM! (ebook edition)

The ebook is available in every local Amazon stores (AT, CO.JP, CO.UK, COM.AU, COM.BR, DE, ES, FR, IN, etc.)

Order this book on Amazon.IT! (print and ebook editions)

Order this book on Kobo! (ebook edition)

For more information on this book, please send us an email at hygeiapress@hygeiapress.com.

“Children of the Mother Goddess. History of Mediterranean Neonates” edited by Vassilios Fanos and Murat Yurdakök

ISBN 9788890438950, 224 pages, € 24, 1st edition: October 2010

Authors: Cristina Areias, Alessandra Atzei, Luigi Cataldi, Marinella Corridori, Giovanni Corsello, Matteo Della Monica, Gian Paolo Donzelli, Thamianos Fanos, Vassilios Fanos, Italo Farnetani, Nadia Maria Filippini, M. Giuseppina Gregorio, Hercília Guimarães, Roberto Mauri, Luigi Memo, Amélia Ricon-Ferraz, Marcella Testa, Teresa Tomé, Francesco Tregnaghi, Kyriakì Tsotra, Alice Vuoso-Mauri, Murat Yurdakök

The leading elements in this volume are the cultural representation of birth and the forms through which its narration and representation develop in the figurative arts, through historical references, mythological tales and legends, traditions, customs and habits. The influence of myth, language and artistic expression on our cultural representation of procreation is manifest, and this way of “narrating” birth resists even today, although it comes into conflict with a more scientific vision of pregnancy and childbirth.
With this book we believe we have contributed to an in-depth examination of illness narratives, thus favouring the search for a convergence between medical language in the sector and the language of cultural experience so that evidence-based medicine does not clash with narrative-based medicine, but that the two languages come together towards a reciprocity that will strengthen the alliance between physician and patient.

Presentation by Giuseppe Buonocore

Presentation by Paolo Giliberti

Presentation by Gian Paolo Donzelli

Introduction
Vassilios Fanos, Murat Yurdakök

1. Birth in Mediterranean Cultures: Searching for the Roots
Luigi Cataldi, M. Giuseppina Gregorio
The Mother Goddess and the evolution of a culture • The sacred marriage of the Goddess: the Mediterranean culture

2. Birth in Ancient Anatolia
Murat Yurdakök
12,000 years ago • Neolithic times • Hattians and Hittites • Ottoman times

3. Birth and Care of the Newborn in Ancient Greece
Vassilios Fanos, Alessandra Atzei, Marinella Corridori
Childbirth • Rituals following birth • Breastfeeding • Abandonment and infanticide • Parents’ attachment to their children

4. Extraordinary Births in the Gods’ Delivery Room
Vassilios Fanos, Thamianos Fanos, Marinella Corridori
The birth of Athena from Zeus’s head • The birth of Dionysus from Zeus’s thigh • Aphrodite’s birth from Uranus’s member • The birth of Agdistis and Erichthonius from the Earth • When the mothers are those who engender

5. The Newborn and the Child in Magna Graecia
Giovanni Corsello
History • Philosophy, science, myth and religion • Play • Nutrition

6. Birth and Care of the Newborn in Ancient Rome
Marinella Corridori, Vassilios Fanos
The reproductive role of the woman • Midwives • Illustrations of childbirth • Factors considered important for childbirth: girdles and knots • Divinities and childbirth • Childbirth and the first treatments of the newborn • Neonatal mortality • Recognition of the neonate • The abandonment (or exposure) of the newborn • The neonate’s bath, swaddling clothes and crib • Breastfeeding • The name

7. Fertility Rites
Italo Farnetani, Vassilios Fanos, Marinella Corridori
Ethnobiology of reproduction • Fertility rites • The power of light

8. History of Breastfeeding
Marcella Testa, Kyriakì Tsotra
The Egyptians • The Greeks • The Etruscans and Italic peoples • The Romans • Conclusions

9. History of Adoption
Francesco Tregnaghi
Adoption in Babylon • The Old Testament • Ancient Egypt • Ancient Greece • Ancient Rome • The Middle Ages • The French Revolution • Modern times: France and Italy

10. Neonatal Medicine in Ancient Art
Murat Yurdakök
Breastfeeding • The first neonatologists • Caesarean birth • The fetus • Congenital anomalies • Twins • Circumcision

11. Birth Defects through History
Luigi Memo, Matteo Della Monica, Roberto Mauri, Alice Vuoso-Mauri
Ancient Egypt • The Middle East • Ancient Greek and Roman Worlds • The Middle Ages and the Renaissance • 16th to 18th Centuries • Victorian Curiosity • Eugenics and the Nazi madness • Current Perspectives • Conclusions

12. “Extraordinary Birth”. History of the Caesarean Section in the Western World
Nadia Maria Filippini
The birth of gods and heroes • The post mortem caesarean • The 18th-century revolution: Gian Battista Bianchi and Francesco Emanuele Cangiamila • The caesarean section on living women

13. Myths about Childbirth
Amélia Ricon-Ferraz, Hercília Guimarães, Cristina Areias, Teresa Tomé
Pregnancy • Childbirth • Puerperium • The newborn

14. Childhood Protection: Amulets and Talismans
M. Giuseppina Gregorio, Luigi Cataldi
Amulets • Talismans • The amulet as a jewel • Nowadays • Conclusions

15. The Past and Future of European Newborns
Hercília Guimarães, Amélia Ricon-Ferraz, Cristina Areias, Teresa Tomé
Looking to the past • What about the future? • Newborn Individualized Developmental Care and Assessment Program (NIDCAP) • Neonatal end-of-life decisions and palliative care • UENPS (Union of European Neonatal & Perinatal Societies) and EFCNI (European Foundation for the Care of Newborn Infants) • Neonatal mortality and morbidity • The near future

Appendix. Birth (Lyrics)
Gian Paolo Donzelli
Choice • Essence • Premonition • Expectation • Labour • Birth • Life • Breastfeeding

References

List of authors

You can also view the book’s table of contents here: link.

The underlying theme of this book is the narration of childbirth and the forms in which it is expressed through the figurative arts, myth, legends and traditions that orient behaviours and legislative measures. History and traditions are a part of a cultural heritage that brings together physicians and patients and these are expressed in a shared language that makes communication possible. – Giuseppe Buonocore (President of the Union of European Neonatal and Perinatal Societies), October 2010

The event of birth has assumed in all epochs and cultures the connotations of myth, the touch of magic, the symbolism of the supernatural, and it is from these roots that have stemmed the rights of the newborn to be brought up and protected as the prime symbol of the mystery of life. Today, when we affirm newborns’ right to the title of “persons”, recalling the past helps us to find the right answers to the many unresolved questions. – Paolo Giliberti (President of the Italian Neonatology Society), October 2010

The book strongly emphasises how birth is a political and social event that belongs to the history of every single neonate-citizen, to the woman or man who procreated it, to the whole of society. This book should be read by all those operating in the neonatological, paediatric and perinatological sciences at any historic, health, psychological, sociological, and anthropological level, as well as all university students during their training in this discipline. – Gianpaolo Donzelli (President of the Italian Perinatal Medicine Society), October 2010

This book is also available in Italian: “Figli della Dea Madre. Storia dei neonati nel Mediterraneo”

The post Children of the Mother Goddess. History of Mediterranean Neonates (also in EBOOK format) appeared first on Hygeia Press.